Clinical outcomes with oral cephalosporins as definitive treatment of Enterobacterales bacteremia from a urinary source based on cefazolin minimum inhibitory concentration
Year: 2026
Type: article
Study design: Observational Study
Abstract: ABSTRACT Cefazolin breakpoints differ for the treatment of Enterobacterales urinary tract infections and systemic infections. A retrospective, exploratory cohort study of 148 patients found no difference in 30-day treatment outcomes based on the blood culture cefazolin minimum inhibitory concentration (≤2 mcg/mL versus 4–16 mcg/mL) for patients transitioned to PO cephalosporins for the treatment of Escherichia coli , Klebsiella pneumoniae , or Proteus mirabilis bacteremia secondary to a urinary source. Further research should confirm these findings.
DOI: 10.1128/aac.01357-25
Institutions: University of Utah, University of Utah Health Care
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7130329705