Work

A Novel CSN5 Inhibitor Drives Tumor-Intrinsic PD-L1 Degradation and Exerts Direct Antitumor Efficacy in Triple-Negative Breast Cancer

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c02669

Authors: Yanjun Wang, Hui Lei, Wenyi Liu, Xindie Li, Siyi Jiang, Hang Zhang, Rui Xiong, Zhiwen Yang, Yu-Hang Yan, Yingying Jiang, Ming Lei, Guo-Bo Li, Hua-Li Wang, Lingling Yang

Institutions: Xihua University, University of Hong Kong - Shenzhen Hospital, Sichuan University, University of Oxford

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Sichuan Province Science and Technology Support Program

Awards: G159317589, G2180269198, G7761322604

OpenAlex ID: W7130346929

FWCI: 3.627

Cites: 47

Cited by: 2

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