Factors Associated With Oral Epithelial Dysplasia in Oral Potentially Malignant Disorders
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Potentially malignant disorders (PMDs) carry an increased risk of malignant transformation, which may vary according to patient-specific characteristics. PURPOSE: The purpose of this study was to measure the association between sociodemographic and clinical characteristics and oral epithelial dysplasia (OED) among patients with PMDs. STUDY DESIGN, SETTING, AND SAMPLE: This retrospective cross-sectional study included participants with PMDs evaluated between 2005 and 2019 at Antônio Pedro University Hospital, Universidade Federal Fluminense, Brazil. Exclusion criteria included lesions not compatible with PMDs after clinical and histopathological review, malignant lesions, lesions associated with candidiasis or trauma, and those located on the lip vermilion. PREDICTOR VARIABLE: The predictor variables were a heterogeneous set of sociodemographic and clinical characteristics. MAIN OUTCOME VARIABLES: The main outcome variable was OED categorized as absent, mild, moderate, or severe. COVARIATES: Not applicable. ANALYSES: or Fisher's exact tests, as appropriate. Bivariate analyses estimated relative risks (RRs) with 95% CIs, with statistical significance set at P ≤ .05. RESULTS: The sample comprised 60 participants (mean age 58.9 years ± 12.4; 51.7% female). The most frequent PMD was leukoplakia (73.3%), followed by leukoerythroplakia (18.3%), proliferative verrucous leukoplakia (PVL, 6.7%), and erythroplakia (3.3%). All participants presented OED, classified as mild in 53.3%, moderate in 30.0%, and severe in 16.7%. Overall, PMD type was not associated with OED severity (P = .2); however, leukoplakia was associated with low-grade OED (P = .04). In bivariate analysis, leukoerythroplakia showed a higher risk of moderate/severe OED compared with leukoplakia (RR = 1.81; 95% CI: 1.04 to 3.14; P = .04), and PVL showed a borderline increased risk (RR = 1.94; 95% CI: 0.99 to 3.82; P = .05). Sociodemographic variables and addictive habits were not associated with OED severity. Clinically, lesion location on the floor of the mouth was observed exclusively among cases with moderate/severe OED (P = .03), and lesion heterogeneity showed a borderline association with moderate/severe OED (P = .05). CONCLUSIONS: Although PMD type was not globally associated with OED severity, leukoplakia was linked to low-grade OED, whereas leukoerythroplakia and PVL tended to show higher OED severity. Lesion heterogeneity and involvement of the floor of the mouth emerged as the most relevant clinical features related to moderate/severe OED, highlighting their relevance in the risk stratification of PMDs.
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,500
OpenAlex ID: W7130348309