Work

A Rare Case Report of Antisynthetase Syndrome With Progressive Myopathy and Interstitial Lung Disease in a 38‐Year‐Old Male

Year: 2026

Type: article

Abstract: Antisynthetase syndrome is a rare autoimmune disorder characterized by a range of clinical features, most commonly associated with autoantibodies targeting aminoacyl-tRNA synthetases. The condition typically presents with a combination of symptoms, including myositis, arthritis, Raynaud's phenomenon, "mechanic's hands," fever, and interstitial lung involvement. Pulmonary manifestations, particularly interstitial lung disease (ILD), are significant prognostic determinants. Management often involves a combination of immunosuppressive agents to address both muscular and respiratory complications. We report the case of a 38-year-old man who developed progressive proximal muscle weakness, arthralgia, Raynaud's phenomenon, and ILD. Laboratory tests indicated elevated muscle enzymes, and anti-Jo-1 antibodies were detected on repeat testings. Electromyography supported a diagnosis of myopathy, while high-resolution computed tomography confirmed ILD. He was treated with corticosteroids, additional immunosuppressants, and plasmapheresis, which resulted in partial symptomatic improvement. Rituximab was considered a potential future treatment option. This case emphasizes the importance of early recognition and prompt, intensive immunosuppressive therapy, along with careful clinical monitoring, to improve outcomes for patients with severe antisynthetase syndrome.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.72059

Authors: Masab Ali, Muhammad Umair Tariq, Muhammad Hassan, Muhammad Husnain Ahmad, Amina Jamil

Institutions: Punjab Medical College, Allied Hospital, S. Tentishev Asian Medical Institute

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820