Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer (Adv. Sci. 10/2026)
Year: 2026
Type: article
Abstract: Heating Cold Breast Cancers Effectively This cover art reimagines Investiture of the Gods. The Lady Shiji represents mTOR-driven immune evasion in triple-negative breast cancer (Skull Mountain). Nezha, representing a gold nanocomposite, strikes with his Spear (mTOR inhibitor) and Universe Ring (photothermal therapy), while Taiyi Zhenren (anti-PD-1) empowers T cells to attack Skull Mountain (tumor). This illustrates the strategy by Jing Jing, Xiaowei Liu, and co-workers to reverse immunosuppression and treat cold tumors. More details can be found in the Research Article (DOI: 10.1002/advs.202513711).
Source: Advanced Science
DOI: 10.1002/advs.73993
Authors: Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $6,730
OpenAlex ID: W7130363135
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