Work

Heterogeneity and plasticity of the naive CD4+ T cell compartment

Year: 2026

Type: article

Abstract: This study describes the transcriptional heterogeneity of murine and human naive CD4 + T cells as comprising multiple discrete clusters that impact CD4 + T cell fate and trajectories. Naive CD4 + T cells experiencing inflammatory environments exhibit an altered transcriptional state that biases their differentiation trajectories.

Source: Cell Reports

DOI: 10.1016/j.celrep.2026.116980

Authors: Alia Sajani, Evelien Schaafsma, Walburga Croteau, Mohamed ElTanbouly, Elizabeth C. Nowak, Chao Cheng, Christopher M. Burns, Mary Jo Turk, Randolph J. Noelle, J. Louise Lines

Institutions: Dartmouth College, Dartmouth Cancer Center, Dartmouth Health, Rockefeller University, Baylor College of Medicine

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620

Funders: Cancer Prevention and Research Institute of Texas, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Acquisition of the NextSeq2000 Sequencing platform to Increase Next Generation Sequencing Throughput While Reducing Costs at Dartmouth, G1556230741, G1782143322, Computational Identification of new candidate drugs for lung cancer treatment, VISTA is a negative checkpoint regulator of innate immunity, G2456550904, G2969172209, G365203686, Targeting VISTA eradicates large, established PD-1/CTLA-4 resistant tumors, G7321402606, Recruitment of Rising Stars, G7570788555

OpenAlex ID: W7130379178

FWCI: 11.32

Cites: 56

Cited by: 5

Related to: