A modified partition of peripapillary atrophy in high myopia based on optical coherence tomography
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective: This study investigates morphological changes in peripapillary atrophy (PPA) in high myopia (HM) patients, aiming to refine PPA zoning characteristics to enhance clinical diagnosis and treatment of HM. Design: This study is categorized as a retrospective cross-sectional model. Methods: We retrospectively reviewed 172 patients (316 eyes) with comprehensive medical records, categorizing them into a pathological myopia (PM) cohort-subdivided into PM1 (≥30 mm), PM2 (≥28 and <30 mm), PM3 (<28 mm)-and a simple HM group, based on fundus pathology and axial length (AL). We collected data on spherical equivalent (SE), best corrected visual acuity (BCVA), intraocular pressure (IOP), AL, and posterior optical coherence tomography (OCT). For posterior OCT, we manually measured improved landmark features based on the original PPA zoning: Scleral Curvature Angle (SCA), Scleral Flange Curvature Angle (SFCA), PPA1-4 zone, scleral flange length (SFL), and mean scleral flange thickness (MSFT). The Bland-Altman method assessed measurement consistency, and statistical comparisons were made of the modified PPA feature parameters across the groups. Results: < 0.01). Conclusion: The modified PPA partition based on OCT imaging identifies 6 key zoning features: PPA1-4, SCA, and SFCA. These are correlated with longer AL and advanced fundus changes in HM patients. In particular, PPA1 and SCA emerge as vital indicators for assessing HM conditions using OCT imaging.
Source: Frontiers in Medicine
Authors: Kaiyao Chi, Biao Li, Tong Guo, Daoxi Lei, Yanlin Zheng, Huili Li
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7130385102