Work

Novel approach for diabetic wound healing: adipose-derived mesenchymal stromal cells Exo@SPHydrogel combined with laser therapy

Year: 2026

Type: article

Abstract: This study investigates the effectiveness of multifunctional hydrogels incorporating chlorophyll derivatives and adipose-derived mesenchymal stromal cells (AD-MSCs) exosomes for promoting wound healing in a rat model. Transcriptome sequencing analysis of rat wound tissues revealed a decrease in levels of endothelial cells and M2-type macrophages. The newly developed hydrogel, adipose-derived mesenchymal stromal cell exosomes@Spirulina Platensis (AD-MSC-exo@SP), demonstrated various functionalities including inhibition of biofilm formation, antimicrobial properties, and stimulation of angiogenesis and M2-type macrophage polarization in vitro. Animal trials showed increased expression of proliferative and angiogenic proteins, enhanced M2-type macrophage polarization, reduced inflammation, and improved antimicrobial effects when combined with laser therapy, leading to accelerated skin wound healing. These findings highlight the potential of the AD-MSC-exo@SP hydrogel as a promising approach to improve wound repair outcomes.

Source: npj Regenerative Medicine

DOI: 10.1038/s41536-026-00459-w

Authors: Weizhi Chen, Jie Hong, Yiliu Wei, Junchen Ye, Qiaoyi Wu

Institutions: Fujian Medical University, First Affiliated Hospital of Fujian Medical University

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,190