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Atomic force microscopy: The creator of a new paradigm from nanoscale topography imaging to mechanobiology and medicine

Year: 2026

Type: article

Abstract: Atomic force microscopy (AFM) has transcended its role as a mere provider of high-resolution imaging in medical research, catalysing a paradigm shift from 'morphological observation' to 'quantitative mechanics' and 'single molecule manipulation'. AFM enables us to directly decipher the 'mechanical language' of living systems, acquiring information on sample topography, mechanical properties, and molecular interactions under near physiological conditions with nanoscale resolution. This review systematically elaborates on how AFM, by providing quantitative, functional, and dynamic nanoscale data, is reshaping the understanding of disease mechanisms. It is also fostering novel precision medicine strategies guided by 'mechanobiology' in areas such as cardiovascular diseases, cancer, and pathogen recognition. AFM not only expands the dimensions of medical research but also provides unprecedented tools and perspectives for disease diagnosis, drug development, and cellular intervention.

Source: Journal of Microscopy

DOI: 10.1111/jmi.70070

Authors: Qianhui Xu, Huaiwei Zhang, Junmei Chen, Danhong Chen, Haijian Zhong, Weidong Zhao

Institution: Gannan Medical University

Language: English

Topic: Force Microscopy Techniques and Applications

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, Gannan Medical University