Work

SGK1 signaling: an important modulator of CFTR function and early immune response in mouse intestine

Year: 2026

Type: article

Abstract: Glucocorticoids rapidly boost intestinal CFTR expression, function, and trafficking through SGK1 and link stress signaling to epithelial secretion and immune control. Deleting Sgk1 blocked glucocorticoid-driven CFTR activation and altered early immune cell recruitment, uncovering SGK1 as a critical regulator of intestinal adaptation to acute stress.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00400.2025

Authors: Caroline Muiler, Anderson Santos, Nadia A. Ameen

Institution: Yale University

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health