Work

Author response: Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

Year: 2026

Type: peer-review

Abstract: Brain slice electrophysiology, immunohistochemistry, and in vivo two-photon calcium imaging identify circuit dysfunction and epilepsy mechanism in a Kcnc1-A421V/+ mouse model of developmental and epileptic encephalopathy.

Source: eLife

DOI: 10.7554/elife.103784.3.sa4

Authors: Eric R Wengert, Sophie R Liebergall, Teresa Jimenez, Melody A Cheng, Kelly H Markwalter, Jerome Clatot, Yerahm Hong, Leroy Arias, Eric D Marsh, Xiaohong Zhang, Theo Tsetsenis, Ala Somarowthu, Naiara Akizu, Ethan M Goldberg

Institutions: Children's Hospital of Philadelphia, University of Pennsylvania

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: University of Pennsylvania, National Institutes of Health, Center for Undergraduate Research and Scholarship, Bowling Green State University, National Institute of Neurological Disorders and Stroke

Award: Training Program in Neuroengineering and Medicine

OpenAlex ID: W7130400153

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