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EXPRESSION OF CONCERN: Simultaneous Modulation of COX‐2, p300, Akt, and Apaf‐1 Signaling by Melatonin to Inhibit Proliferation and Induce Apoptosis in Breast Cancer Cells

Year: 2026
Type: article
Abstract: EXPRESSION OF CONCERN: J. Wang, X. Xiao, Y. Zhang, D. Shi, W. Chen, L. Fu, L. Liu, F. Xie, T. Kang, W. Huang, and W. Deng, “Simultaneous Modulation of COX-2, p300, Akt, and Apaf-1 Signaling by Melatonin to Inhibit Proliferation and Induce Apoptosis in Breast Cancer Cells,” Journal of Pineal Research 53, no. 1 (2012): 77–90, https://doi.org/10.1111/j.1600-079X.2012.00973.x. This Expression of Concern is for the above article, published online on 03 January 2012 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Gianluca Tosini; and John Wiley & Sons Ltd. A third party raised concerns that a FACS plot had been duplicated between Figures 1B and 6C, while both are intended to represent different treatments and quantification. An investigation by the publisher confirmed this duplication and also found evidence of image duplication between Figures 3D and 4A involving western blot data, as well as a panel mismatch in Figure 6D involving fluorescence data. The authors responded to an inquiry by the publisher with an explanation and some additional data, but they could not supply all of the original raw data for the article. The Expression of Concern has been agreed to because the concerns of image and data duplication in the article cannot be resolved. The authors were informed of the Expression of Concern.
DOI: 10.1111/jpi.70122
Language: English
Open Access status: bronze
OpenAlex ID: W7130405511
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