Work

Pseudoendocrine Sarcoma: Unusual Manifestation in the Lower Leg

Year: 2026

Type: article

Abstract: Pseudoendocrine sarcoma is a recently described rare soft tissue neoplasm. The tumor predominantly affects older adults, with the paravertebral soft tissue as a predilection site. We report on an unusual location of pseudoendocrine sarcoma in the right gastrocnemius muscle of a 59-year-old male patient. Histology showed a remarkable neuroendocrine-like morphology. Immunohistochemically, the tumor cells were negative for chromogranin, synaptophysin, and INSM-1 but positive for beta-catenin, CD56, and multifocally for S100. By molecular analysis, an S37F point mutation in exon 3 of the CTNNB1 gene was detected. This case, to our knowledge, illustrates a hitherto unreported location of a pseudoendocrine sarcoma in the lower leg. The relevant differential diagnoses are discussed with special regard to CD56 and S100.

Source: Cureus

DOI: 10.7759/cureus.103833

Authors: Torsten Hansen, Mathias Esser, Reiner Wirbel, Cornelia S. L Müller, Abbas Agaimy

Institutions: Verbundkrankenhaus Bernkastel, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7130409495