Brønsted Acid-Catalyzed Multicomponent Phosphonylation/Cyclization Strategy for the Synthesis of Phosphinylated 2 H -Isoindoles
Year: 2026
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide A Brønsted acid-catalyzed three-component modular phosphonylation/cyclization protocol has been established for the efficient synthesis of phosphinylated 2 H -isoindoles, employing o -propargyl alcohol benzaldehydes, diarylphosphine oxides, and arylamines as starting materials. This metal-free cascade transformation is characterized by mild conditions, broad substrate compatibility, gram-scale synthesis, and one-pot construction of C–P, C–N, and C═C bonds. Mechanistic studies revealed that this chemistry involves Kabachnik–Fields reaction, 5- exo - dig cyclization, and aromatization. Interestingly, these isoindole-substituted phosphine oxides emit bright fluorescence in the aggregated states under UV irradiation.
Source: ACS Omega
Authors: Nan Yang, Xin Chang, Ni-Ni Zhou, Yi-Fan Niu, Chen-Xiang Ma, Hai-Tao Zhu, An-Xi Zhou, Hai-Tao Feng
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
OpenAlex ID: W7130411115