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Bone Health After Metabolic and Bariatric Surgery: Osteometabolism Biomarkers, Bone Mineral Density, and Microarchitecture

Year: 2026

Type: article

Abstract: OBJECTIVE: The effects of metabolic and bariatric surgery on bone health still require further investigation. Osteometabolism biomarkers, bone microarchitecture (BM), and mineral density (BMD) of patients who have undergone Roux-en-Y gastric bypass (RYGB) within 2-5 years from surgery were compared to non-surgical age-, sex-, and BMI-matched controls. METHODS: ) and 21 controls (CG). Circulating levels of albumin, calcium, phosphorus, magnesium, 25(OH) vitamin D, parathyroid hormone (PTH), carboxy-terminal telopeptide of type 1 collagen (CTX-1), and amino-terminal propeptide of type 1 procollagen (P1NP) were assayed. BMD and BM were assessed by dual-energy X-ray absorptiometry (DXA) and three-dimensional high-resolution peripheral quantitative computed tomography system (HR-pQCT). RESULTS: BG presented with higher circulating phosphorus, PTH, CTX-1, and P1NP and lower 25(OH) vitamin D compared to CG. DXA parameters did not differ between groups. However, HR-pQCT revealed significant derangements in BM (trabecular thickness, cortical bone density, and outer trabecular volumetric BMD) in BG. BG showed tibia-specific trabecular microarchitecture impairment, while sex and BMI showed the expected associations with BM measures. CONCLUSIONS: RYGB was associated with detrimental effects on osteometabolism biomarkers, as well as on density and structural parameters of BM. Early preventive strategies aimed at mitigating these deleterious effects should be systematically evaluated to minimize their long-term impact. TRIAL REGISTRATION: ClinicalTrials.gov (NCT04193397).

Source: Obesity

DOI: 10.1002/oby.70132