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Injectable in Situ Cross-linked Oxidized Alginate-Gelatin-Based Hydrogels for Cartilage Tissue Engineering

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The present study introduces an injectable oxidized alginate-gelatin hydrogel system for cartilage tissue engineering, employing a combination of covalent and noncovalent cross-linking mechanisms. Specifically, the network is formed through Schiff’s Base reactions alongside enzymatic and ionic cross-linking. The hydrogels were investigated regarding their mechanical properties, swelling and degradation behavior, injectability, and cytocompatibility. The results indicated tailorable mechanical properties with an effective modulus ranging from 12 to 20 kPa, depending on the enzymatic cross-linker concentration, while demonstrating suitable injectability required for clinical applications with injection forces in the range of 3–5 N. Moreover, the syringe-mixing approach of in situ cross-linked hydrogels showed favorable cell–material interactions with chondrogenic ATDC5 cells.

Source: ACS Biomaterials Science & Engineering

DOI: 10.1021/acsbiomaterials.5c01832

Authors: Lisa Schöbel, Juri Artes, Markus Lorke, Aldo R. Boccaccini

Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500