Work

The simplified method for quantifying metabolic syndrome (siMS) score reflects an increased cardiometabolic burden: adiposity, hemodynamics, and HRV findings in young adults

Year: 2026

Type: article

Abstract: Purpose: Metabolic Syndrome (MetS) increases cardiovascular disease risk, yet early identification of pre-MetS remains challenging. The Simple Method for Quantifying MetS (siMS) score offers potential for detecting cardiometabolic burden in younger and middle-aged, relatively healthy populations. Methods: = 26) groups based on the median siMS score and compared central hemodynamic parameters, heart rate variability (HRV), and microvascular function as independent predictors of cardiometabolic risk between these groups. Anthropometrics, body composition, hemodynamics (e.g., central blood pressure [BP], mean arterial pressure [MAP]), HRV (e.g., %R-R intervals > 50 msec, pNN50; high-frequency power), microvascular reactivity (near-infrared spectroscopy vascular occlusion test), blood glucose and lipid profiles, and dietary intake were assessed using established protocols. Results: ≤ 0.003), indicating increased cardiometabolic burden. No differences were observed in blood glucose, lipids, dietary intakes, or microvascular reactivity. Conclusion: These findings suggest that higher siMS scores reflect early cardiometabolic risk through adverse hemodynamic and autonomic profiles, even in the absence of overt MetS, metabolic abnormalities, or detectable microvascular dysfunction. The siMS score may serve as a proactive tool for identifying at-risk individuals, supporting targeted interventions to mitigate long-term cardiometabolic risk.

Source: Journal of Diabetes & Metabolic Disorders

DOI: 10.1007/s40200-026-01870-2