Year: 2026
Type: article
Study design: Case Report
Abstract: Gastric neuroendocrine tumors (gNETs) are rare gastric neoplasms that often present with non-specific symptoms and may mimic other submucosal gastric lesions. We report a case of a WHO Grade 1 gastric neuroendocrine tumor in a 67-year-old male who presented with a 7-month history of epigastric pain, early satiety, and melena. Esophagogastroduodenoscopy revealed a broad-based ulcerated fundal mass, initially suspected to be a gastrointestinal stromal tumor. Histopathological examination with immunohistochemistry confirmed a well-differentiated neuroendocrine tumor with strong chromogranin A positivity. Contrast-enhanced computed tomography demonstrated a localized submucosal fundal lesion without nodal or distant metastasis. The patient underwent partial gastrectomy with complete excision of the tumor. Histology confirmed clear resection margins. The postoperative course was uneventful. This case emphasizes the diagnostic importance of histopathology and immunohistochemistry and supports surgical resection as effective treatment for localized, low-grade gastric neuroendocrine tumors.
Source: Cureus
Institution: Muhimbili University of Health and Allied Sciences
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7130503488