Work

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR

Year: 2026

Type: article

Source: Nature Biotechnology

DOI: 10.1038/s41587-026-03013-7

Authors: Xiaolin Wei, Yueyuan Xu, Dongchan Yang, Kyukwang Kim, Lizhi Yi, Wenzhe Luo, Xin Lin, Yu Xiang, Ashley B. Williams, Xiaotao Wang, Sweta Srivas, Christabel Tan, Kan Zhang, Wei Li, Yang Eric Li, Feng Yue, Z. Josh Huang, Inkyung Jung, Yarui Diao

Institutions: Duke University, Duke Medical Center, Korea Advanced Institute of Science and Technology, Northwestern University, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Children's National, Washington University in St. Louis

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Glenn Foundation for Medical Research, National Research Foundation, Fondation pour la Recherche Médicale, Ministry of Science and ICT, South Korea, National Institutes of Health, Samsung, National Heart, Lung, and Blood Institute

Awards: G1337196915, Large scale discovery and validation of brain cell type enhancers for viral targeting and circuit manipulation, The 4D nucleome of muscle regeneration in ischemia-induced tissue damage and repair, G9000226041, Medical Scientist Training Program Training Grant

OpenAlex ID: W7130503566

FWCI: 20.02

Cites: 61

Cited by: 11

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