Work

Krüppel-like factor 2 regulates renin expression in mature juxtaglomerular cells

Year: 2026

Type: article

Abstract: Using renin lineage cell-specific Klf2 knockout mice, we identify Klf2 as a transcriptional effector linking hemodynamic pressure sensing to renin transcription in mature juxtaglomerular cells. Loss of Klf2 blunted the upregulation of renin in response to low-salt/captopril and the pressure-responsiveness to low and high perfusion.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00416.2025

Authors: Hiroki Yamaguchi, Jason P. Smith, Omar Guessoum, Drishti Daga, Manako Yamaguchi, Lucas Ferreira de Almeida, Daisuke Matsuoka, Hirofumi Watanabe, Silvia Medrano, R. Ariel Gomez, Maria Luisa S. Sequeira-Lopez

Institutions: University of Virginia, University of Pennsylvania, Niigata University

Language: English

Topic: Renin-Angiotensin System Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Minnesota, University of Cincinnati, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G5283304385, Regulation of Cell Fate during Kidney Development and Disease

OpenAlex ID: W7130506298

FWCI:

Cites: 54

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