Polyphenol‐Based Biomaterials Against Cancer Radio/Chemotherapy‐Induced Intestinal Toxicity
Year: 2026
Type: article
Abstract: Radiotherapy and chemotherapy are widely employed in cancer treatment but frequently induce intestinal toxicity, which significantly compromises patients’ quality of life and limits therapeutic efficacy. Polyphenols, a diverse class of natural compounds with broad biological activities, have demonstrated protective effects against radio/chemotherapy‐induced intestinal injury through antioxidation, anti‐inflammation, DNA damage repair, and microbiota modulation, etc. However, the limited stability, bioavailability, and targeting efficiency of polyphenols hinder their oral use in clinical practice. This review summarizes the mechanisms and oral delivery challenges of polyphenols. Furthermore, it highlights recent advances in oral delivery systems designed to address the oral limitations of polyphenols. Challenges in developing such systems and potential future directions are also discussed, aiming to provide new perspectives for oral polyphenol formulations to prevent/treat radio/chemotherapy‐induced intestinal toxicity.
Source: Advanced NanoBiomed Research
Authors: Jixu Lu, Jing Chen, Ji Zhu, Lixin Ru, Dongxiao Zhang
Institutions: Chinese Academy of Sciences, Southwest Medical University, Affiliated Hospital of Southwest Medical University, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Jiaxing University, First Hospital of Jiaxing, Wenzhou Medical University, Zhejiang Chinese Medical University, Huzhou Central Hospital
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,940
OpenAlex ID: W7130509448