Work

Glucose metabolic dysregulation of diabetes and Its role in atrial fibrillation pathogenesis

Year: 2026

Type: article

Abstract: Atrial fibrillation (AF) is the most prevalent persistent arrhythmia in clinical practice, with a complex pathogenesis that remains incompletely understood. Emerging evidence underscores a strong association between diabetes and the occurrence of AF, highlighting a significantly elevated risk among diabetic patients. This increased susceptibility is not solely attributable to chronic hyperglycemia but is also shaped by blood glucose fluctuations and dysregulated glucose metabolism. In this review, we summarize the mechanisms by which hyperglycemia and blood glycemic variability contribute to the onset of AF, and the potential involvement of abnormal glucose metabolism pathways and metabolic disturbances induced by diabetes in the pathogenesis of AF.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2025.1711069

Authors: Yuqi Chen, Min Xu, Ke Wei, Nan Ma

Institutions: Shanghai Jiao Tong University, XinHua Hospital

Language: English

Topic: Atrial Fibrillation Management and Outcomes

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801