Neurocysticercosis in transition: expanding clinical spectrum, evolving diagnostics, and emerging therapies
Year: 2026
Type: article
Abstract: larvae, remains a leading cause of acquired epilepsy in endemic regions and an increasingly recognized imported disease elsewhere. The traditional view of NCC as a solitary parenchymal cyst causing seizures has shifted to a heterogeneous syndrome shaped by parasite burden, stage, location, and host immune response. Clinical manifestations extend beyond seizures to headaches, cognitive impairment, psychiatric symptoms, visual loss, movement disorders, and stroke. Progress in neuroimaging, serology, and molecular diagnostics has improved case detection and disease phenotyping, while management increasingly relies on stage and compartment specific combinations of antiparasitic drugs, anti-inflammatory therapy, and neurosurgical or endoscopic interventions for extraparenchymal disease and hydrocephalus. Persistent gaps include limited randomized evidence, incomplete validation of diagnostic algorithms, and constrained access to advanced care in high-burden regions, underscoring the need for coordinated research and implementation strategies to reduce NCC's global neurological impact.
Source: Frontiers in Pharmacology
Institutions: Kookmin University, Malla Reddy Institute Of Medical Sciences, Graphic Era Hill University, Graphic Era University, Sharda University, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Lovely Professional University, Noida Institute of Engineering and Technology Pharmacy Institute, Noida Institute of Engineering and Technology, Chitkara University, Saveetha University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7130512690