Hidradenitis suppurativa in patients with inflammatory bowel disease: a national multicenter study from the GETECCU-ENEIDA Registry
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: Hidradenitis suppurativa (HS) is a chronic, recurrent skin disease that may be associated with inflammatory bowel disease (IBD). Objectives: This study aimed to describe the features and therapeutic requirements of IBD and HS in patients who present both entities and the risk factors for HS development in patients with IBD. Methods: Case-controlled, retrospective study of all patients diagnosed with IBD-HS in the ENEIDA registry. Cases were paired 1:2 with controls (IBD without HS). Design: This was a retrospective, case–control study. Results: A total of 819 patients were included: 273 patients with IBD-HS and 546 controls. Female sex (62% vs 44%, p = 0.0001), active smoking (45% vs 18%, p = 0.0001), Crohn’s disease (CD; 83% vs 55%, p = 0.0001), perianal disease (59% vs 33%, p = 0.0001), extraintestinal manifestations (38% vs 17%, p = 0.0001), and psychiatric disorders (18% vs 2%, p < 0.05) were more frequent among patients with IBD-HS than in controls. The average body mass index was greater in the IBD-HS group. The most frequently HS-affected locations were axillary (57%) and genital (43%) areas. Use of biologicals and CD-related perianal surgery was more common among patients with CD-HS (77% vs 66%, p = 0.003; 37% vs 13%, p < 0.001), compared to controls with only CD. Conclusion: Patients with IBD-HS exhibit a distinctive phenotype with higher therapeutic requirements for the subset of patients with CD-HS compared to those without HS. Assessment of this comorbidity should be considered in patients with suggestive skin lesions and IBD to improve the outcomes of both conditions.
Authors: Lucía Madero-Velázquez, Ruth de Francisco, Belen Herreros, Carmen Yagüe, Luis Bujanda, Xavier Calvet, Angel Ponferrada, Mariam Aguas, Francisco Rodríguez-Moranta, Ignacio Marín-Jiménez, Lourdes Catalá, Carla Gargallo-Pueyo, José Huguet, Francisco Mesonero, David Monfort, Mónica Sierra-Ausín, Laura Igualada, Elena Ricart-Gomez, María González-Vivo, María José García, Alejandro Hernandez Camba, Ainara Elorza, Lucía Zabalza-San Martín, Laura Ramos, María Dolores Martín-Arranz, Isabel Ruiz-Núñez, Pilar Martínez-Montiel, Pilar Soto, Cristina Roig, María Molina, Miriam Mañosa, Cristina Alba, Manuel Barreiro-de Acosta, Javier P. Gisbert, Patricia Ramírez de la Piscina, Rufo Lorente, Yamile Zabana, Belen Botella, Sabino Riestra, Olivia Belen-Galipienso, David Busquets, Federico Argüelles, José Carlos Pascual, Pedro Zapater, Eugeni Domènech, Ana Gutiérrez
Institutions: Hospital General Universitario de Alicante Doctor Balmis, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, Hospital Marina Baixa, Hospital Universitario Miguel Servet, University of the Basque Country, Biogipuzkoa Health Research Institute, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Donostiako Unibertsitate Ospitalea, Universitat Autònoma de Barcelona, Corporació Sanitària Parc Taulí, Institute of Research and Innovation Parc Tauli, Hospital Universitario Infanta Leonor, Hospital Universitari i Politècnic La Fe, Bellvitge University Hospital, Institut d'Investigació Biomédica de Bellvitge, Universidad Complutense de Madrid, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario de Elche, Hospital Clínico Universitario Lozano Blesa, Instituto de Investigación Sanitaria Aragón, Hospital General Universitario De Valencia, Hospital Universitario Ramón y Cajal, Consorci Sanitari de Terrassa, Complejo Asistencial Universitario de León, Hospital Universitario Fundación Alcorcón, Hospital Clínic de Barcelona, Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer, Hospital Del Mar, Marqués de Valdecilla University Hospital, Instituto de Investigación Marqués de Valdecilla, Hospital Universitario Nuestra Señora de Candelaria, Hospital de Galdakao, Navarre Institute of Health Research, Hospital Universitario de Canarias, Hospital Universitario La Paz, Hospital Universitario Río Hortega, Hospital Universitario 12 De Octubre, Instituto Maimónides de Investigación Biomédica de Córdoba, Hospital Universitario Reina Sofía, University of Córdoba, Hospital de Sant Pau, Hospital General Universitari de Castelló, Hospital Clínico San Carlos, Complejo Hospitalario Universitario de Santiago, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, Hospital Universitario Araba, Hospital General Universitario de Ciudad Real, University Hospital Mútua de Terrassa, Mútua Terrassa, Universitat de Barcelona, Institut d'Investigació Biomèdica de Girona, Hospital Universitari de Girona Doctor Josep Trueta, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Universitat de Miguel Hernández d'Elx, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital Universitari Germans Trias i Pujol
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,700
OpenAlex ID: W7130513161