Work

Extracellular vesicle transcriptomes in human urine capture kidney adaptation to sodium intake

Year: 2026

Type: article

Abstract: The kidneys adapt to changes in Na + intake by regulating tubular Na + transport, and we investigated whether the RNA content of urinary EVs (uEV) reflects the physiological responses to dietary Na + intake in humans. Dietary Na + intake altered both transcript abundance and kidney-derived uEV levels, which correlated with renin, aldosterone, and blood pressure levels. Thus, uEV transcriptomics provide a noninvasive window for studying the molecular control of kidney Na + handling in humans.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00433.2025

Authors: Iben Skov Jensen, Rikke Zachar, Boye L. Jensen, Per Svenningsen

Institutions: University of Southern Denmark, Odense University Hospital

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green