Year: 2026
Type: article
Abstract: Background Acute lung injury underlies most of the lung diseases and can further develop to pulmonary fibrosis which caused high mortality and currently with no effective treatment regime. P-coumaric acid is a phenolic acid derived from a variety of vegetables and fruits and have anti-oxidant, anti-microbial, anti-inflammatory and anti-tumor properties. And its effect on acute pulmonary lung is not explored. Thus, the study investigated the protective action of p-coumaric acid on bleomycin-induced acute lung injury in mice. Methods Five groups with each having 6 Albino mice (SHAM, BLM, BLM/PCA/50, BLM/PCA/100 and BLM/MEF/100) were included in the study and treated with a single intra-tracheal instillation of bleomycin. p-coumaric acid (PCA) @ 50 mg/kg bw and 100 mg/kg bw and Metformin @100 mg/kg (as control drug) were administered for 7 days intraperitoneally after bleomycin instillation. Results In this study, administration of p-coumaric acid significantly attenuated oxidative stress and inflammation through reduced inflammatory cells infiltration and cytokines production (IL-6 and TNF-α) and decreased early fibrosis as manifested by decreased level of hydroxyproline, IL-13 and TGF-β along with decrease expression of vimentin and alpha-smooth actin. The p-coumaric acid@100 mg/kg showed the most significant therapeutic effect. Conclusions Thus, p-coumaric acid could improve the bleomycin induced acute lung injury through attenuation of oxidative stress, inflammation, early fibrosis and EMT.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7130521060