Work

Enhancing IgG fragment crystallizable sialylation improves the therapeutic activity of IL-23 cytokine blockade

Year: 2026

Type: article

Abstract: The manuscript demonstrates that the activity of cytokine blocking antibodies can be enhanced by introducing a highly sialylated IgG Fc-domain.

Source: JCI Insight

DOI: 10.1172/jci.insight.198630

Authors: Sebastian Kämpf, Marjan Hematianlarki, Leon Altmann, Jessica M. Bright, Alyssa M.A. Toda, Zohreh Mirzapoor, Valentin Zollner, Anja Werner, Johanna Bulang, Barbara Radovani, Miriam Wöhner, William Avery, Mark J. Karbarz, Pamela B. Conley, Greg P. Coffey, Falk Nimmerjahn

Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,100

Funder: Deutsche Forschungsgemeinschaft

Awards: G1691701901, G2367504651, G3169169474, G3222430274, G4839504938, G5027059815, G8401613838, G8683273117, G8976656641

OpenAlex ID: W7130550144

FWCI:

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