Work

Next-generation CRISPR screens enable causal systems immunology

Year: 2026

Type: article

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20241266

Authors: Hao Shi, Hongbo Chi

Institution: St. Jude Children's Research Hospital

Language: English

Topic: CRISPR and Genetic Engineering

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Lupus Research Alliance, American Lebanese Syrian Associated Charities, National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: Bidirectional metabolic signaling in follicular helper T cell differentiation, Nutrient sensing and lysosomal signaling in regulatory T cells and immune tolerance, G9000017361, G9000213926, G9000305082, Transcriptional and metabolic heterogeneity in T cell differentiation, Regulation of T cell memory in tissue immunity, Integrating systems immunology with immunometabolism and cancer immunity, Enabling immunotherapy for high-risk Group 3 medulloblastoma via systems immunology

OpenAlex ID: W7130597739

FWCI: 3.656

Cites: 126

Cited by: 2

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