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ANCA-Negative Granulomatous Polyangiitis Presenting With Isolated Oral and Esophageal Involvement

Year: 2026

Type: article

Abstract: Granulomatosis with polyangiitis (GPA) is a necrotizing small vessel vasculitis, which is most classically associated with lung and renal involvement. In this article, we present a young man who presented with oral ulcers, odynophagia, and foreign body sensation in the esophagus. Upper endoscopy revealed many esophageal ulcers with biopsies highly suspicious for GPA and no infectious etiologies identified on extensive testing. To our knowledge, this is a unique diagnosis of ANCA-negative GPA in a patient presenting with isolated oral and esophageal involvement.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000002022

Authors: Hadley Greenwood, Jeffrey Kaplan, Benjamin Click

Institution: University of Colorado Anschutz

Language: English

Topic: Vasculitis and related conditions

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7130649113

FWCI:

Cites: 5

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