Work

Balancing Act: Lessons From Comanaging Patients With Inflammatory Bowel Disease and HIV/AIDS

Year: 2026

Type: article

Abstract: Patients with inflammatory bowel disease (IBD) and human immunodeficiency virus (HIV) present unique challenges due to overlapping immune dysregulation and heightened infection risk. Although immunosuppressive therapy is central to management of moderate to severe IBD, concurrent HIV infection complicates both diagnostic evaluation and therapeutic decisions. Outcomes in this population remain poorly defined, with limited evidence available to guide management. This case series evaluates 3 challenging cases that demonstrates the diagnostic uncertainty and therapeutic complexity encountered when IBD and HIV coexist, underscoring the need for individualized, multidisciplinary care and further investigation to optimize outcomes in this vulnerable population.

Source: ACG Case Reports Journal

DOI: 10.14309/crj.0000000000002001

Authors: Erick Cruz Grave, Paul Paik, John Kim, Florence-Damilola Odufalu

Institutions: University of Southern California, Los Angeles Medical Center

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Bristol-Myers Squibb, Pfizer