Work

In vivo Expansion of Regulatory T cells via an Engineered IL-2 Mutein to Suppress Autoimmune Glomerulonephritis

Year: 2026

Type: article

Abstract: Rationale: Regulatory T (Treg) cells suppress autoimmunity and restrain inflammatory responses, showing promising potential in autoimmune glomerulonephritis (GN) therapy with minimizing nonspecific immunosuppression. Although low-dose interleukin-2 (IL-2) has been shown to promote Treg expansion, its clinical utility is constrained by its short half-life and concurrent effector T cell activation. Methods: T cells from donors and peripheral blood mononuclear cells (PBMCs) from autoimmune GN patients. Results: T cells of healthy donors or PBMCs from autoimmune GN patients. Conclusions: holds significant promise as an alternative immunotherapeutic strategy for controlling autoimmune GN while reducing nonspecific immunosuppression.

Source: Theranostics

DOI: 10.7150/thno.126588