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Additional file 1 of Serum norethisterone (NET) levels in NET-enanthate (NET-EN) injectable contraception users substantially interfere with testosterone immunoassay measurements and confound interpretation of biological outcomes

Year: 2025

Type: article

Abstract: Additional file 1: Supplementary Table and Figures. Supplementary Table S1: Median concentrations of testosterone at D0 in samples with or without detectable concentrations of NET. Supplementary Figure S1: Bland-Altman plots for assessing differences in testosterone concentrations determined by CMIA and UHPLC-MS/MS at baselineand 25 weeks. Supplementary Figure S2: Percentage under- and overestimation of testosterone concentrations by CMIA compared to UHPLC-MS/MS in paired samples. Supplementary Figure S3: In NET-EN users, testosterone concentrations measured by CMIA are higher than those measured by UHPLC-MS/MS. Supplementary Figure S4: Chemical structures of testosterone, norethisterone, medroxyprogesterone, DHEA-S, 19-nortestosterone and levonorgestrel

Source: Figshare

DOI: 10.6084/m9.figshare.29946183

Authors: Avenant, Chanel, Moliki, Johnson Mosoko, Bick, Alexis J., Dlamini, Sigcinile, Singata-Madliki, Mandisa, Hofmeyr, G. Justus, Chen, Pai-Lien, Storbeck, Karl-Heinz, Africander, Donita J., Erikson, David W., Hapgood, Janet P.

Institutions: University of Cape Town, University of the Witwatersrand, Walter Sisulu University, University of Botswana, Family Health International 360, Stellenbosch University, Oregon Health & Science University

Language: English

Topic: Clinical Laboratory Practices and Quality Control

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7130697068

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