Additional file 1 of Mental, physical, and respiratory health in people with tuberculosis in Southern Africa: a multi-country cohort analysis
Year: 2025
Type: article
Abstract: Additional file 1: Tables S1–S6. Table S1 Number of study participants and proportion of visits, missing visits, deceased patients, and pending visits during the study period (at the start, end of tuberculosis treatment, and 6 months post-tuberculosis treatment). Table S2 Summary of mental and physical health-related quality of life (QoL) scores by study visit (tuberculosis treatment start, end of treatment, 6 months post-treatment). Table S3 Estimation results for the change in the QoL z-scores by predictor and time. Table S4 Estimated associations of baseline QoL scores with death during treatment. Table S5 Estimated associations of baseline QoL scores with any non-fatal serious adverse events during treatment. Table S6 Estimated associations of baseline QoL scores with missing follow-up visit at the end of treatment. Figures S1–S10. Fig. S1 Pairwise correlations between quality of life (QoL) scores by study visit. Fig. S2 Estimated proportion (in %) of patients with depressive symptoms for different cut-off values of the PHQ-9 score. Fig. S3 Estimated proportion (in %) of patients with impaired QoL by country. Fig. S4 The proportion of patients with impaired mental and physical QoL by study visit. Fig. S5 Trajectories of patients with depressive symptoms at any study visit (start of tuberculosis treatment, end of treatment, and 6 months post-treatment). Fig. S6 Distribution of the continuous QoL scores study visit. Fig. S7 Estimated change in QoL outcomes between end versus start of tuberculosis treatment and 6 months post-tuberculosis versus end of tuberculosis treatment. Fig. S8 Sensitivity analysis: estimated change in QoL when including missing follow-up visits and deaths for which the QoL scores were imputed. Fig. S9 Simulation analysis: estimated change in QoL for patients with follow-up visits (blue) vs hypothetical change in QoL for patients with missing follow-up visits or deaths so that the net effect would be zero (red). Fig. S10 Estimated change in QoL z-score (median as dot, 95%-CrI as lines) per quantile of the QoL score distribution at the end of tuberculosis treatment by patient characteristic.
Source: Figshare
Authors: Banholzer, Nicolas, Muula, Guy, Mureithi, Fiona, Evans, Denise, Huwa, Jacqueline, Rafael, Idiovino, Kunzekwenyika, Cordelia, Jinga, Nelly, Fernando, Amina, Thawani, Agness, Schmutz, Remo, Bolton, Carolyn, Günther, Gunar, Egger, Matthias, Haas, Andreas D., Sweetland, Annika C., Ballif, Marie, Fenner, Lukas
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7130734374
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