Work

Integrative vitamin D-inflammatory-coagulation biomarker index predicts COVID-19 severity

Year: 2026

Type: article

Abstract: Vitamin D deficiency is common in hospitalized COVID-19 patients and is associated with increased severity. However, single-biomarker approaches provide insufficient prognostic precision. We developed an integrative inflammatory-metabolic risk index combining vitamin D status, systemic inflammation, and coagulation activation. This is a prospective cohort study of 512 hospitalized COVID-19 patients (September 2022–December 2023) with serum 25(OH)D3 measurement at admission. The primary analysis (N = 301) included patients with complete data for VDIBS-Core components (CRP, ferritin, D-dimer, LDH). The Vitamin D Inflammatory Burden Score-Core (VDIBS-Core

Source: Repository of the University of Ljubljana (University of Ljubljana)

Authors: Osredkar, Joško, Godnov, Uroš, Siuka, Darko

Institutions: University of Ljubljana, Ljubljana University Medical Centre, University of Primorska

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Javna Agencija za Raziskovalno Dejavnost RS

Awards: Metabolic and hereditary factors of reproductive health-Labour III, Environmental and genetic factors in autism spectrum disorders