The Dual Associations of Peripheral Inflammatory Cells With Brain Reorganization in Insular Gliomas With/Without Epilepsy: An Exploratory Analysis
Year: 2026
Type: article
Study design: Observational Study
Abstract: ABSTRACT Objectives The insula was invaded by gliomas and epilepsy occurred frequently. Our study aimed to reveal brain reorganization and explore potential peripheral biomarkers that reflect these processes. Methods 51 insular glioma‐related epilepsy (IRE) and 52 without epilepsy (IRnE) patients were included. Deep learning was used for tumor segmentation to generate masks for subsequent analyses. Virtual brain grafting was applied to eliminate the mass effect. Morphological analyses relied on MATLAB, SPM, and CAT12. Statistical analyses included χ 2 test, t test, one‐way ANOVA, regression, principal component, and correlation analysis. Results Increased gyrification ( GI ) occurred on the contralateral side of IRnE. Increased gray matter volume and toroidal GI ( Toro GI ) appeared on the same and contralateral sides of IRE, respectively. Elevated Toro GI showed an initial predictive value for the control of postoperative epilepsy and was negatively associated with blood white cell, monocyte, and neutrophil counts in IRE. The opposite relationship was observed for GI in IRnE. Significance The brain would conduct different reorganization models to adapt to IRE and IRnE. These processes may be associated with specific peripheral inflammatory cells. Longitudinal studies and explorations of more specific biomarkers are necessary for elucidating the causal relationships and providing suggestions for therapeutic concepts of different insular glioma subtypes.
Source: CNS Neuroscience & Therapeutics
DOI: 10.1002/cns.70788
Institutions: Capital Medical University, Beijing Tian Tan Hospital
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,140
Award: G185016844
OpenAlex ID: W7130818241