Work

Lirafugratinib attenuates ABCG2-dependent drug efflux and restores chemosensitivity in multidrug-resistant nonsmall cell lung cancer cells

Year: 2026

Type: article

Source: Drug Metabolism and Disposition

DOI: 10.1016/j.dmd.2026.100258

Authors: Chung-Pu Wu, Yen-Ching Li, Bing-Huan Lin, Megumi Murakami, Yu-Tzu Chang, Yu-Shan Wu, Tai-Ho Hung, Suresh.V. Ambudkar

Institutions: Chang Gung University, Chang Gung Memorial Hospital, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Tunghai University, Keelung Chang Gung Memorial Hospital

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science and Technology Council, Chang Gung Memorial Hospital, Chang Gung Memorial Hospital, Linkou, Taichung Veterans General Hospital, National Institutes of Health, National Cancer Institute

Awards: G2876395352, G4945954051, Prevalence and Risk Factors for Thyroid Dysfunction in Pregnancy in Taiwan, G6325253128, Investigating the Drug-Nutrient Interaction of Bioactive Compounds in Dietary Supplements Mediated by Inhibition and Induction of the Atp-Binding Cassette Transporters Abcb1 and Abcg2, Biochemical Analysis of Multidrug Resistance-linked Transport Proteins

OpenAlex ID: W7130829730

FWCI:

Cites: 33

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