Increased cortical thickness and decreased brain age among special operations veterans with blast TBI after a magnesium-ibogaine protocol
Year: 2026
Type: article
Study design: Clinical Trial
Abstract: = 22). Longitudinal analyses assessed cortical thickness, subcortical volume, and predicted brain age (pBA), estimated from T1 scans. pBA was significantly reduced at 1 month relative to baseline (-1.3 years). Cortical thickness analysis revealed post-treatment increases in 11 regions. Subcortical analyses revealed significant volumetric expansion in 8 regions. Magnesium-ibogaine therapy was associated with increased cortical thickness, subcortical expansion, and reduced pBA at 1 month. Although T1s are sensitive to nonstructural changes, the overall direction of effect is consistent with neuroplastic change.
Source: iScience
Authors: Andrew D. Geoly, John P. Coetzee, Derrick Matthew Buchanan, Wiebke Struckmann, Bora Kim, Malvika Sridhar, Azeezat Azeez, Jennifer I. Lissemore, Kirsten Cherian, Afik Faerman, Jackob N. Keynan, Prakamya Singal, Alaa Shanbour, Igor D. Bandeira, Ian H. Kratter, Maheen M. Adamson, Manish Saggar, Cammie Rolle, Nolan R. Williams
Institutions: Stanford University, VA Palo Alto Health Care System
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,240
Funder: Stanford University
OpenAlex ID: W7130833121