Placental small extracellular vesicles as modulators of bisphenol A-induced oxidative stress and mitochondrial activation in human astrocytoma cells (U-373 MG)
Year: 2026
Type: article
Abstract: The study demonstrates that BPA induces oxidative stress and mitochondrial dysfunction in human astrocytes. It introduces a novel role of sEVs in counteracting these effects by reducing ROS, restoring mitochondrial activity, and upregulating antioxidant enzymes. Notably, sEVs from BPA-exposed placental explants were more efficiently incorporated into astrocytes, suggesting an adaptive protective mechanism. These findings highlight a potential fetal neuroprotective role of placental sEVs against environmental stressors.
Institution: University of Siena
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G1311510893, G1358849479, G2678912845
OpenAlex ID: W7130841793