Engineering non-exponential proliferation in Escherichia coli using functionalized protein aggregates
Year: 2026
Type: article
Abstract: ABSTRACT Uncurbed exponential proliferation might not always be required for genetically modified microorganisms, and might even cause unpredictable liabilities in their behavior and impact. We therefore constructed a bacterial chassis that adheres to linear proliferation for a finite number of generations, based on the asymmetric segregation of a gradually declining intracellular protein aggregate that is engineered to produce a conditionally essential metabolite such as cAMP.
Source: Nature Communications
Institution: KU Leuven
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
Awards: Bacterial protein aggregates as novel tools in synbio applications, Dynamics and differentiating capacity of stress-induced protein aggregates in bacteria, Next-generation bioprocess engineering: phage-based synthetic reprogramming of bacterial bioreactor populations, Synthetic Transduction as a Novel Tool for Population Programming, Bacterial protein aggregates as novel tools in synbio applications
OpenAlex ID: W7130845889