Work

Oncostatin M-induced ABCC2 suppression sensitizes hepatocellular carcinoma cells to chemotherapeutics

Year: 2026

Type: article

Abstract: Oncostatin M (OncM/OSM), a member of the interleukin-6 family, was first characterized for inhibition of tumour cell proliferation. Physiologically, this cytokine participates in haematopoietic processes and is involved in normal functioning of systems and organs. However, Oncostatin M exhibits also modulatory properties on activity of cytochrome P-450 and ABC superfamily (ATP-binding cassette) proteins, which are considered to be cornerstones of multidrug resistance (MDR) phenotype. The aim of this study was to determine the role and effect of OSM on the expression and activity of ABCC2 (cMOAT), an ABC transporter, in a hepatocellular carcinoma line (Hep G2) as an model. Our results suggest that this cytokine reduces expression of ABCC2 which may have potent consequences for the biliary transport.

Source: Biomedicine & Pharmacotherapy

DOI: 10.1016/j.biopha.2026.119105

Authors: Maciej Przywarty, Błażej Rychlik, Anna Wieczorek-Błauż, Andrzej Błauż

Institution: University of Łódź

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,610