Work

High-fat diet and obesity each increase tumor cell proliferation and muscle wasting in experimental cancer cachexia

Year: 2026

Type: article

Abstract: High-fat diet and obesity are linked to increased cancer risk, but the impact on cachexia development remains unclear. Using mouse models, this study demonstrates high-fat diet and obesity each exacerbate muscle wasting, tumor growth, and tumor and muscle IL-6 expression. Our study reveals distinct, overlapping effects with implications for cancer and cachexia interception.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00545.2025

Authors: Brittany R. Counts, Andrea Bonetto, Ho Lam Chan, Ernie D. Au, Yanlin Jiang, Marion E. Couch, Denis C. Guttridge, Michael C. Ostrowski, Leonidas G. Koniaris, Teresa A. Zimmers

Institutions: Oregon Health & Science University, University of Miami, Indiana University School of Medicine, University of Colorado Anschutz, Indiana University, Medical University of South Carolina

Language: English

Topic: Nutrition and Health in Aging

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Pennsylvania Department of Health, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1581679921, G2609401473, G3348980537, G4717460674, G4936257046, PQ6: Lipocalin-2 as a therapeutic target for prevention of cancer cachexia, The role of the macroenvironment in pancreatic cancer-induced cachexia, OHSU Knight Cancer Institute

OpenAlex ID: W7130855913

FWCI: 11.81

Cites: 40

Cited by: 3

Related to: