Work

The Effect of the Gem‐Dimethyl Unit in the Gold‐Catalyzed Cycloisomerization of Aliphatic 1‐Bromoalkynes

Year: 2026

Type: article

Abstract: The introduction of the gem‐dimethyl unit in different positions resulted in sharp conformational effects in the gold‐catalyzed cycloisomerization of aliphatic 1‐bromoalkynes. Additionally, the cyclopropane unit has been used as an isostere of the gem‐dimethyl unit. Surprisingly, in this context, such replacement was unsuccessful. The experimental observations were rationalized with the aid of density functional theory (DFT) calculations.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500996

Authors: Rubén Miguélez, Omar Arto, Hanna Siera, Isabel Merino, Gebhard Haberhauer, Pablo Barrio

Institutions: Universidad de Oviedo, University of Duisburg-Essen

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

Funders: Deutsche Forschungsgemeinschaft, Universidad de Oviedo, Agencia Estatal de Investigación