Work

Forensic Metrology in Neuroscience: A Systems Calibration Framework for Human-Aligned CNS Drug Development

Year: 2026

Type: article

Abstract: This paper examines why biological data obtained from animal models cannot be assumed to represent human physiology. It analyses structural, kinetic, temporal, and systemic differences between species and shows how these divergences introduce systematic error into biomedical inference. The paper argues that translational research requires a metrological framework capable of measuring and correcting these divergences, rather than relying on assumptions of similarity. The Cidad Method is presented as a calibration protocol designed to quantify cross‑species divergence and evaluate when surrogate models can or cannot be aligned with human reference standards.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.18731972

Author: Cidad, Sue

Institutions: National Hospital for Neurology and Neurosurgery, University College London

Language: English

Topic: Animal testing and alternatives

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7130935468

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