Work

Aryl Halide-Driven Nickel Photocatalytic Decarboxylative Elimination

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Nickel photoredox catalytic reactions have found ample application in cross-coupling. However, understanding its mechanistic behavior might identify a bifurcation point, thus allowing for divergent reactivity. In this work, we describe a nickel photoredox decarboxylative β-hydride elimination reaction. Structural-activity analysis of aryl halide additives allowed for tunability, and mechanistic investigations confirm a rate-determining nickel-catalyzed β-hydride elimination step. A consecutive two-photon process yields ( Z )-enamides from a combination of decarboxylative elimination and Dexter energy transfer from the same iridium photocatalyst.

Source: ACS Catalysis

DOI: 10.1021/acscatal.5c08828

Authors: Ning Wei, Sebastian B. Beil

Institutions: University of Groningen, Max Planck Institute for Chemical Energy Conversion, University of Duisburg-Essen

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Rijksuniversiteit Groningen, Max-Planck-Gesellschaft