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BLRM-EffTox : A seamless two-stage phase 1 Bayesian logistic regression design incorporating efficacy-toxicity trade-off for dose optimization

Year: 2026

Type: article

Source: Journal of Biopharmaceutical Statistics

DOI: 10.1080/10543406.2026.2627385

Authors: Xin Liu, Cynthia Basu, Arnab Kumar Maity, Yuan Ji, Haitao Chu, Wei Zhong

Institutions: The Ohio State University, Pfizer (United States), Boehringer Ingelheim (Germany), University of Chicago, BioNTech (Germany)

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W7131073241

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Cites: 28

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