Year: 2026
Type: article
Abstract: A concise route toward (-)-strychnine is presented. Key steps include the photoredox-catalytic C2-cyanomethylation of Boc-l-Trp-OMe and a condensation-electrocyclization cascade linking two fragments convergently to obtain an advanced intermediate. A photochemical decarboxylation provided convenient access to strychnofluorine, which could be transformed through the Wieland-Gumlich aldehyde to strychnine. All building blocks can be traced back to renewable sources.
Source: JACS Au
Institution: Johannes Gutenberg University Mainz
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,500
OpenAlex ID: W7131078620