Comparative Study on the Safety and Efficacy of Aspirin plus Rivaroxaban vs Clopidogrel plus Apixaban in Deep Vein Thrombosis Patients
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: This research aims to evaluate and contrast the effectiveness and safety profiles of Aspirin with Rivaroxaban (RA) and Clopidogrel with Apixaban (CA) in minimizing thromboembolic risks among patients diagnosed with Deep Vein Thrombosis (DVT). Methodology: A forward-looking observational study was conducted involving 40 participants with confirmed DVT, allocated evenly between two treatment groups. Parameters assessed included recurrence and progression of DVT, bleeding events, death rates, and relevant laboratory markers. Data analysis involved Chi-square and T-tests using SPSS v26.0. Findings: The patients in the CA group had a significantly lower rate of DVT recurrence (5% vs. 45%; p= 0.0035) and a tendency towards less disease progression (10% vs. 35%; p = 0.051). The incidence of major and mild hemorrhage, as well as fatality rates, did not exhibit significant differences. However, the baseline INR, haemoglobin, and platelet count were significantly different (p<0.05) from the normal range. Conclusion: Clopidogrel-apixaban seemed to be more effective in the prevention of DVT recurrence without increasing the risk to the patients’ safety compared to Aspirin-Rivaroxaban. This study needs to be followed by broader, randomised trials to confirm these findings.
Author: Neeraj Moitra
Institution: Malla Reddy University
Language: English
Subfield: Internal Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7131111668
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