Year: 2026
Type: preprint
Abstract: The choice of sample size in the context of co-primary endpoints for a randomised trial is discussed. Current guidance can leave endpoints with unequal marginal power. A method is provided to achieve equal marginal power by using the flexibility provided in multiple testing procedures. A comparison is made to several choices of rule to determine the sample size, in terms of the study design and its operating characteristics.
Source: arXiv (Cornell University)
Author: Bond, Simon
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7131126498
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