Work

Kidney Volume and Molecular Processes are Dynamic in ADPKD

Year: 2026

Type: article

Abstract: Introduction Although progress has been made toward elucidating cellular pathways related to initial cystogenesis in autosomal dominant polycystic kidney disease (ADPKD), the mechanisms that contribute to disease progression and the timing of transitions remain largely unclear. We hypothesized that the predominant kidney biological processes in Pkd1 RC/RC and other ADPKD models are highly dynamic throughout the disease, providing insights into the resulting kidney phenotype and conform well to those observed in human ADPKD. Methods Kidney volume changes by class and age were determined in a large, well-characterized cohort of individuals with ADPKD and long follow-up. Similarly, Pkd1 RC/RC and wild-type mice were studied longitudinally, and their kidney volume changes and function analyzed. Kidney mRNA profiles (mRNA-sequencing) of Pkd1 RC/RC mice were investigated at early, mid and late stages, compared to those reported in other ADPKD models and humans with ADPKD. Results In most individuals with ADPKD, kidney volume continues to increase, but the rate of growth differs between classes and within severe classes by age. Kidney volume and function changes in Pkd1 RC/RC mice conform well to the kidney volume changes in class 1C patients during adulthood. The kidney transcriptomic profile in Pkd1 RC/RC mice evolves over the course of the disease, underscoring their highly dynamic kidney phenotype, presents several commonalities with other ADPKD models and is relevant to human ADPKD. Conclusions Our study suggests that, in ADPKD, different therapeutic strategies might be beneficial at different disease stages and identifies target candidate pathways for biomarker discovery that could be further investigated in humans.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2026.106376