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Transfection via RNA-Based Nanoparticles: Comparing Encapsulation vs Adsorption Approaches of RNA Incorporation

Year: 2025

Type: editorial

Abstract: Historically, RNA delivery via nanoparticles has primarily relied on encapsulation, as demonstrated by lipid nanoparticles in SARS-CoV-2 vaccines. Concerns about RNA degradation on nanoparticle surfaces initially limited the exploration of adsorption-based approaches. However, recent advancements have renewed interest in adsorption as a viable alternative. This Viewpoint explores the approaches of RNA incorporation in nanoparticles, comparing encapsulation, adsorption, and the combination of encapsulation and adsorption, and presents a framework to guide the selection of the most suitable strategy based on general characteristics.

Source: Bioconjugate Chemistry

DOI: 10.1021/acs.bioconjchem.5c00028

Authors: Amy E. Laturski, Maria T. Dulay, Jillian L. Perry, Joseph M. DeSimone

Institutions: Stanford University, University of North Carolina at Chapel Hill

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4407938999

Cites: 145

Cited by: 6

Related to: 10